Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a Metaanalysis / 中国当代儿科杂志

OBJECTIVES@#To systematically evaluate the efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn (PPHN).@*METHODS@#Chinese Journal Full-text Database, Weipu Database, Wanfang Data, China Biology Medicine disc, PubMed, Web of Science, Embase, and Cochrane Library were searched for literature on bosentan in the treatment of PPHN published up to August 31, 2021.@*RESULTS@#A total of 8 randomized controlled trials were included for Meta analysis. The results of the Meta analysis showed that compared with the control group, the bosentan treatment group had a significantly lower treatment failure rate (RR=0.23, P<0.001), a significantly greater reduction in pulmonary artery pressure [mean difference (MD)=-11.79, P<0.001)], significantly greater increases in oxygen partial pressure (MD=10.21, P=0.006) and blood oxygen saturation (MD=8.30, P<0.001), and a significantly shorter length of hospital stay (MD=-1.35, P<0.001). The descriptive analysis showed that the bosentan treatment group had a lower degree of tricuspid regurgitation than the control group after treatment. The main adverse reactions of bosentan treatment included abnormal liver function, anemia and edema. The results of subgroup analysis based on treatment regimen, research area, and drug dose were consistent with those before stratification.@*CONCLUSIONS@#Bosentan is effective in the treatment of PPHN. However, when using bosentan, attention should be paid to adverse reactions such as abnormal liver function.

Association between / 中国当代儿科杂志

OBJECTIVES@#To study the association of β2-drenergic receptor (@*METHODS@#A total of 143 children with asthma who attended the hospital from October 2016 to October 2020 were enrolled as the asthma group, among whom 61 children had mild symptoms (mild group) and 82 children had moderate-to-severe symptoms (moderate-to-severe group). A total of 137 healthy children were enrolled as the control group. Peripheral venous blood samples were collected from the two groups. The SNaPshot SNP technique was used to analyze the SNP and haplotypes of the @*RESULTS@#Polymorphisms were observed in the @*CONCLUSIONS@#SNP/haplotype of the

Effects of Long Non-coding RNA Plasmacytoma Variant Translocation 1 Gene on Inflammatory Response and Cell Migration in Infected Gastric Epithelial Cell Line / 中国医学科学院学报

To investigate the mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in gastric cancer caused by (HP) infection. The expression of PVT1 was detected by quantitative real-time polymerase chain reaction in HP-infected normal gastric epithelial cells GES-1. Gastric cancer cell line SGC-7901 was transfected with PVT1 small interfering RNA and co-cultured with HP,and then the inflammatory cytokines such as tumor necrosis factor-α (TNF-α),interleukin (IL) -1β,IL-6 and IL-8 were detected. After PVT1 was knocked down,the effects of PVT1 on the proliferation and migration of gastric cancer cells were examined by cell scratch assay. RNA-pulldown combined with mass spectrometry was used to detect the protein binding to PVT1,and the result of mass spectrometry was verified by RNA-pulldown combined with Western blot. In HP-infected normal gastric epithelial cells GES-1,quantitative real-time polymerase chain reaction showed that PVT1 was significantly up-regulated (=7.160,=0.019). PVT1 was knocked down in gastric cancer cells,and then infected with HP. The expressions of inflammatory factors including TNF-α (=3.899,=0.011),IL-1β (=14.610,=0.000),and IL-8 (=6.557,=0.001) were significantly inhibited. Although PVT1 knockdown had no significant effect on the proliferation ability of gastric cancer cells,it inhibited the migration of cells. PVT1 might interact with RPS8 protein. PVT1 may act as a pro-inflammatory factor and regulate gastric cancer caused by HP infection.

Application of quality control circle activity in the treatment of infantile pneumoniabyaerosolinhalation / 中国生化药物杂志

Objective To research application of quality control circle activity in the treatment of infantile pneumonia by aerosol inhalation. Methods Carry out the quality control circle activity with the theme of "improving the efficiency of the oxidation atomization inhalation", using the method of PDCA cycle, statistics of inhalation of children, analyze the reasons for the failure of atomization inhalation, set up the improvement target, make the countermeasure and organize the implementation. Then clinical symptoms (the time of evacuation, the time of lung rale disappearance and the time of fever suppression ), hospitalization time, Heart failure rate, nosocomial infection rate, recurrence rate, compliance, satisfaction degree, treatment effect were compared two groups of quality control circle activities before and after. Results After implementation, children with wheeze disappearance time, pulmonary rales disappeared time, cooling time, hospitalization time were significantly lower than the before implementation, the difference was statistically significant(P<0.05); Incidence of heart failure, nosocomial infection rate, recurrence rate were significantly lower than the before implementation, the difference was statistically significant(P<0.05), compliance were significantly higher than the before implementation, the difference was statistically significant(P<0.05); Nursing satisfaction were significantly higher than the before implementation, the difference was statistically significant(P<0.05); total effective rate were significantly higher than the before implementation, the difference was statistically significant(P<0.05). Conclusion Quality control circle activity can achieve satisfactory results in the treatment of children's pneumonia by aerosol inhalation, can reduce the occurrence of adverse events, is conducive to the prognosis of children, so as to improve treatment efficacy and satisfaction.

Application of quality control circle activity in the treatment of infantile pneumoniabyaerosolinhalation / 中国生化药物杂志

Objective To research application of quality control circle activity in the treatment of infantile pneumonia by aerosol inhalation. Methods Carry out the quality control circle activity with the theme of "improving the efficiency of the oxidation atomization inhalation", using the method of PDCA cycle, statistics of inhalation of children, analyze the reasons for the failure of atomization inhalation, set up the improvement target, make the countermeasure and organize the implementation. Then clinical symptoms (the time of evacuation, the time of lung rale disappearance and the time of fever suppression ), hospitalization time, Heart failure rate, nosocomial infection rate, recurrence rate, compliance, satisfaction degree, treatment effect were compared two groups of quality control circle activities before and after. Results After implementation, children with wheeze disappearance time, pulmonary rales disappeared time, cooling time, hospitalization time were significantly lower than the before implementation, the difference was statistically significant(P<0.05); Incidence of heart failure, nosocomial infection rate, recurrence rate were significantly lower than the before implementation, the difference was statistically significant(P<0.05), compliance were significantly higher than the before implementation, the difference was statistically significant(P<0.05); Nursing satisfaction were significantly higher than the before implementation, the difference was statistically significant(P<0.05); total effective rate were significantly higher than the before implementation, the difference was statistically significant(P<0.05). Conclusion Quality control circle activity can achieve satisfactory results in the treatment of children's pneumonia by aerosol inhalation, can reduce the occurrence of adverse events, is conducive to the prognosis of children, so as to improve treatment efficacy and satisfaction.